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What is haemostasis, and why it is important
Blood is of prime importance in the normal physiologic function of our major organ systems. An important function of blood is to maintain an intact circulatory system following trauma.
The process of blood clotting, or coagulation, is a very rapid response to tissue damage where the exposure of tissue factor (also known as thromboplastin) containing cells to the bloodstream through damage to vessel walls initiates a cascade system.the Haemostasis process
How does it work, and what happens
The goal of the cascade is to form fibrin which will form a mesh within the platelet aggregate to stabilize the clot. The cascade system uses a series of enzymes to work in rapid succession: Once activated, tissue factor binds and activates factor VII which initiates the cascade.
Factor VII is activated through auto-cleavage to factor VIIa which along with co-factor VIIIa converts factor X to Xa . Factor Xa along with co-factor Va converts factor II (prothrombin) to factor IIa (thrombin).
Finally factor IIa (thrombin) converts fibrinogen to fibrin leading to fibrin deposition and the activation of platelets to form blood clots.
Haemostasis occurs in the following major events
Limits the flow of blood to the area of injury. Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium.
Platelets become activated by thrombin and aggregate at the site of the injury to form a temporary loose platelet plug. Platelets clump by binding to collagen that becomes exposed following rupture of the endothelial lining of vessels.
Fibrin stability mesh
To enhance stability of the initially loose platelet plug, a fibrin mesh (also called the clot) forms and entraps the plug. Finally, the clot must be dissolved in order for normal blood flow to resume following tissue repair.
Thrombin has a large array of functions. Its primary role is the conversion of fibrinogen to fibrin that is the building block of the haemostatic plug.
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Where our products is used
Ferrosan Medical Devices A/S has strong capabilities within Operations and Technology Development. Being a business development and manufacturing house and focus on these activities within the value chain, we strongly believe that this is where we best utilize our capabilities and provide added value to our distribution partners but foremost to the surgeons and nurses who uses our products in critical surgical settings.
We are more than 190 employees divided into operations and development. Our headquarters are located in Soeborg, close to Copenhagen, where we have production, laboratories, administration, business development, research & development, engineering, regulatory affairs, quality assurance, supply chain and sales & marketing.